The player first travels there on Daegun's orders to board a ship instead of taking the High Road, where an old friend of his can secure a passage to Neverwinter. At the time of the player character's first arrival, Highcliff is plagued by many lizardfolk who sink any outbound ships and raze farmlands, hoping to drive humans away. The player has to resolve the matter before securing passage.
In Act III, Highcliff is besieged by the lizardfolk, now led by an influencial prophet. Depending on how the player handles it, the lizardfolk may join as allies at Crossroad Keep.